Interações medicamentosas
Blinatumomab + Tacrolimus
Gravidade: Moderada
Blinatumomab and Tacrolimus: moderate interaction.
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Resumo
Cytokine release at the start of blinatumomab treatment can temporarily suppress CYP450 enzymes, which may raise tacrolimus concentrations. Elevated tacrolimus levels increase the risk of nephrotoxicity and neurotoxicity.
O que esta interação significa em palavras simples
Blinatumomab and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Blinatumomab belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Por que acontece
Transient cytokine-mediated suppression of CYP3A4 reduces tacrolimus metabolism.
O que fazer
Monitor tacrolimus trough levels and renal function closely during the first days of each blinatumomab cycle. Reduce the tacrolimus dose as needed.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Para assinantes do Pro+
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Outras interações de Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicada
- Bcg vaccine live + Tacrolimus Contraindicada
- Cidofovir + Tacrolimus Contraindicada
- Cyclosporin + Tacrolimus Contraindicada
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicada
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicada
Outras interações de Blinatumomab
- Blinatumomab + Carbamazepine Moderada
- Blinatumomab + Cyclosporin Moderada
- Blinatumomab + Ethosuximide Moderada
- Blinatumomab + Phenytoin Moderada
- Blinatumomab + Quinidine Moderada
- Blinatumomab + Quinine Moderada
Perguntas frequentes
Can I take Blinatumomab with Tacrolimus?
MediHelp rates the interaction as moderate. Blinatumomab and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytokine release at the start of blinatumomab treatment can temporarily suppress CYP450 enzymes, which may raise tacrolimus concentrations. Elevated tacrolimus levels increase the risk of nephrotoxicity and neurotoxicity.
How serious is the interaction between Blinatumomab and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough levels and renal function closely during the first days of each blinatumomab cycle. Reduce the tacrolimus dose as needed.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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