Interações medicamentosas
Brimonidine + Selegiline
Gravidade: Contraindicada
Brimonidine and Selegiline: contraindicated interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Brimonidine labelling forbids use with MAO inhibitors, and selegiline is an MAO-B inhibitor that loses selectivity at higher or transdermal doses. Systemic absorption of the alpha-2 agonist could lead to unpredictable blood-pressure changes, and the effect on catecholamine handling is poorly characterised.
O que esta interação significa em palavras simples
Brimonidine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Brimonidine belongs to Miscellaneous; Selegiline belongs to Central Nervous System.
Por que acontece
Uncertain: MAO inhibition may alter handling of circulating amines and potentiate systemic alpha-2 agonist cardiovascular effects
O que fazer
Avoid brimonidine in patients taking selegiline; use a different intraocular-pressure-lowering agent such as a prostaglandin analogue or beta-blocker where appropriate.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Brimonidine e Selegiline, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Selegiline
- Amitriptyline + Selegiline Contraindicada
- Amoxapine + Selegiline Contraindicada
- Atomoxetine + Selegiline Contraindicada
- Benzphetamine + Selegiline Contraindicada
- Buprenorphine long-acting + Selegiline Contraindicada
- Bupropion-naltrexone + Selegiline Contraindicada
Outras interações de Brimonidine
- Brimonidine + Isocarboxazid Contraindicada
- Brimonidine + Linezolid Contraindicada
- Brimonidine + Phenelzine Contraindicada
- Brimonidine + Procarbazine Contraindicada
- Brimonidine + Rasagiline Contraindicada
- Brimonidine + Tranylcypromine Contraindicada
Perguntas frequentes
Can I take Brimonidine with Selegiline?
MediHelp rates the interaction as contraindicated. Brimonidine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Brimonidine labelling forbids use with MAO inhibitors, and selegiline is an MAO-B inhibitor that loses selectivity at higher or transdermal doses. Systemic absorption of the alpha-2 agonist could lead to unpredictable blood-pressure changes, and the effect on catecholamine handling is poorly characterised.
How serious is the interaction between Brimonidine and Selegiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid brimonidine in patients taking selegiline; use a different intraocular-pressure-lowering agent such as a prostaglandin analogue or beta-blocker where appropriate.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
