Interações medicamentosas
Buspirone + Selegiline
Gravidade: Contraindicada
Buspirone and Selegiline: contraindicated interaction.
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Resumo
Selegiline (an MAO-B inhibitor that loses selectivity at higher or transdermal doses) added to buspirone, a serotonin 5-HT1A partial agonist, has been associated with raised blood pressure and with serotonergic toxicity. Buspirone labelling advises against concurrent MAOI use.
O que esta interação significa em palavras simples
Buspirone and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Buspirone belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Por que acontece
Combined serotonergic activity with MAO inhibition; possible pressor reaction
O que fazer
Avoid the combination. Wait at least 14 days after stopping selegiline before starting the other drug.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Para assinantes do Pro+
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Outras interações de Selegiline
- Amitriptyline + Selegiline Contraindicada
- Amoxapine + Selegiline Contraindicada
- Atomoxetine + Selegiline Contraindicada
- Benzphetamine + Selegiline Contraindicada
- Brimonidine + Selegiline Contraindicada
- Buprenorphine long-acting + Selegiline Contraindicada
Outras interações de Buspirone
- Buspirone + Isocarboxazid Contraindicada
- Buspirone + Linezolid Contraindicada
- Buspirone + Phenelzine Contraindicada
- Buspirone + Procarbazine Contraindicada
- Buspirone + Selegiline transdermal Contraindicada
- Buspirone + Tranylcypromine Contraindicada
Perguntas frequentes
Can I take Buspirone with Selegiline?
MediHelp rates the interaction as contraindicated. Buspirone and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline (an MAO-B inhibitor that loses selectivity at higher or transdermal doses) added to buspirone, a serotonin 5-HT1A partial agonist, has been associated with raised blood pressure and with serotonergic toxicity. Buspirone labelling advises against concurrent MAOI use.
How serious is the interaction between Buspirone and Selegiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Wait at least 14 days after stopping selegiline before starting the other drug.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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