Interações medicamentosas
Buspirone + Tranylcypromine
Gravidade: Contraindicada
Buspirone and Tranylcypromine: contraindicated interaction.
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Resumo
Tranylcypromine (an irreversible non-selective MAO inhibitor) added to buspirone, a serotonin 5-HT1A partial agonist, has been associated with raised blood pressure and with serotonergic toxicity. Buspirone labelling advises against concurrent MAOI use.
O que esta interação significa em palavras simples
Buspirone and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Buspirone belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Por que acontece
Combined serotonergic activity with MAO inhibition; possible pressor reaction
O que fazer
Avoid the combination. Wait at least 14 days after stopping tranylcypromine before starting the other drug.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Buspirone
- Buspirone + Isocarboxazid Contraindicada
- Buspirone + Linezolid Contraindicada
- Buspirone + Phenelzine Contraindicada
- Buspirone + Procarbazine Contraindicada
- Buspirone + Selegiline Contraindicada
- Buspirone + Selegiline transdermal Contraindicada
Outras interações de Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicada
- Amitriptyline + Tranylcypromine Contraindicada
- Amoxapine + Tranylcypromine Contraindicada
- Atomoxetine + Tranylcypromine Contraindicada
- Benzphetamine + Tranylcypromine Contraindicada
- Brimonidine + Tranylcypromine Contraindicada
Perguntas frequentes
Can I take Buspirone with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Buspirone and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tranylcypromine (an irreversible non-selective MAO inhibitor) added to buspirone, a serotonin 5-HT1A partial agonist, has been associated with raised blood pressure and with serotonergic toxicity. Buspirone labelling advises against concurrent MAOI use.
How serious is the interaction between Buspirone and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Wait at least 14 days after stopping tranylcypromine before starting the other drug.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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