Interações medicamentosas
Buspirone + Phenelzine
Gravidade: Contraindicada
Buspirone and Phenelzine: contraindicated interaction.
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Buspirone with a nonselective MAOI such as phenelzine has been associated with hypertensive reactions and risk of serotonin syndrome. Buspirone labeling contraindicates its use with MAOIs. The reaction can be severe and may need hospital care.
O que esta interação significa em palavras simples
Buspirone and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Buspirone belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Por que acontece
Phenelzine inhibits MAO, raising monoamine levels, while buspirone is a serotonergic 5-HT1A partial agonist, so serotonergic toxicity may result; the hypertensive mechanism is not fully established.
O que fazer
Do not use together. Allow at least 14 days after stopping phenelzine before starting buspirone, and about a week after stopping buspirone before starting an MAOI.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Referências
Outras interações de Phenelzine
- 5-HTP + Phenelzine Contraindicada
- Amitriptyline + Phenelzine Contraindicada
- Amoxapine + Phenelzine Contraindicada
- Atomoxetine + Phenelzine Contraindicada
- Benzphetamine + Phenelzine Contraindicada
- Brimonidine + Phenelzine Contraindicada
Outras interações de Buspirone
- Buspirone + Isocarboxazid Contraindicada
- Buspirone + Linezolid Contraindicada
- Buspirone + Procarbazine Contraindicada
- Buspirone + Selegiline Contraindicada
- Buspirone + Selegiline transdermal Contraindicada
- Buspirone + Tranylcypromine Contraindicada
Perguntas frequentes
Can I take Buspirone with Phenelzine?
MediHelp rates the interaction as contraindicated. Buspirone and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Buspirone with a nonselective MAOI such as phenelzine has been associated with hypertensive reactions and risk of serotonin syndrome. Buspirone labeling contraindicates its use with MAOIs. The reaction can be severe and may need hospital care.
How serious is the interaction between Buspirone and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Allow at least 14 days after stopping phenelzine before starting buspirone, and about a week after stopping buspirone before starting an MAOI.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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