Interações medicamentosas
Butabarbital + Tinidazole
Gravidade: Moderada
Butabarbital and Tinidazole: moderate interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Barbiturates are enzyme inducers and may lower tinidazole concentrations, potentially reducing its antimicrobial effect. The effect is predicted from the related nitroimidazole metronidazole and from induction principles rather than extensively studied.
O que esta interação significa em palavras simples
Butabarbital and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Por que acontece
Barbiturate induction of hepatic CYP enzymes increases tinidazole metabolism.
O que fazer
Monitor clinical response to tinidazole, particularly in serious infections. Consider a longer course or alternative therapy if response is inadequate.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Tinidazole
- Disulfiram + Tinidazole Contraindicada
- Ethanol + Tinidazole Grave
- Fexinidazole + Tinidazole Grave
- Lopinavir + Tinidazole Grave
- Nilotinib + Tinidazole Grave
- Ritonavir + Tinidazole Grave
Perguntas frequentes
Can I take Butabarbital with Tinidazole?
MediHelp rates the interaction as moderate. Butabarbital and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates are enzyme inducers and may lower tinidazole concentrations, potentially reducing its antimicrobial effect. The effect is predicted from the related nitroimidazole metronidazole and from induction principles rather than extensively studied.
How serious is the interaction between Butabarbital and Tinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to tinidazole, particularly in serious infections. Consider a longer course or alternative therapy if response is inadequate.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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