Interações medicamentosas
Butorphanol + Clobazam
Gravidade: Grave
Butorphanol and Clobazam: major interaction.
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Resumo
Opioids combined with benzodiazepines such as clobazam cause additive sedation and respiratory depression, and may lead to coma or death.
O que esta interação significa em palavras simples
Butorphanol and Clobazam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Butorphanol belongs to Musculoskeletal; Clobazam belongs to Central Nervous System.
Por que acontece
Additive CNS and respiratory depression via opioid receptors and enhanced GABA-A receptor signalling.
O que fazer
Reserve concurrent use for patients without alternatives, using the lowest doses and shortest duration. Monitor respiratory rate and sedation closely.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicada
- Butorphanol + Sodium oxybate Contraindicada
- Alfentanil + Butorphanol Grave
- Alprazolam + Butorphanol Grave
- Alvimopan + Butorphanol Grave
- Amobarbital + Butorphanol Grave
Outras interações de Clobazam
- Amobarbital + Clobazam Grave
- Buprenorphine + Clobazam Grave
- Carisoprodol + Clobazam Grave
- Chloral hydrate + Clobazam Grave
- Clobazam + Clozapine Grave
- Clobazam + Codeine Grave
Perguntas frequentes
Can I take Butorphanol with Clobazam?
MediHelp rates the interaction as major. Butorphanol and Clobazam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids combined with benzodiazepines such as clobazam cause additive sedation and respiratory depression, and may lead to coma or death.
How serious is the interaction between Butorphanol and Clobazam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve concurrent use for patients without alternatives, using the lowest doses and shortest duration. Monitor respiratory rate and sedation closely.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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