Interações medicamentosas
Chloral hydrate + Clobazam
Gravidade: Grave
Chloral hydrate and Clobazam: major interaction.
Última atualização Fontes: US FDA label
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Resumo
Clobazam is a benzodiazepine, and combining it with chloral hydrate increases sedation and the risk of respiratory depression. Impaired cognition and falls are more likely in older or frail patients.
O que esta interação significa em palavras simples
Chloral hydrate and Clobazam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloral hydrate belongs to Central Nervous System; Clobazam belongs to Central Nervous System.
Por que acontece
Additive CNS depression through enhanced GABAergic inhibition.
O que fazer
Avoid concurrent use where possible; otherwise use the lowest effective doses and monitor sedation and respiratory function. Caution against alcohol and other depressants.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Chloral hydrate
Outras interações de Clobazam
- Amobarbital + Clobazam Grave
- Buprenorphine + Clobazam Grave
- Butorphanol + Clobazam Grave
- Carisoprodol + Clobazam Grave
- Clobazam + Clozapine Grave
- Clobazam + Codeine Grave
Perguntas frequentes
Can I take Chloral hydrate with Clobazam?
MediHelp rates the interaction as major. Chloral hydrate and Clobazam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clobazam is a benzodiazepine, and combining it with chloral hydrate increases sedation and the risk of respiratory depression. Impaired cognition and falls are more likely in older or frail patients.
How serious is the interaction between Chloral hydrate and Clobazam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; otherwise use the lowest effective doses and monitor sedation and respiratory function. Caution against alcohol and other depressants.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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