Interações medicamentosas
Clobazam + Codeine
Gravidade: Grave
Clobazam and Codeine: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Benzodiazepines combined with opioids carry a boxed warning for profound sedation, respiratory depression, coma and death. Clobazam may also weakly inhibit CYP2D6, which could reduce activation of codeine to morphine.
O que esta interação significa em palavras simples
Clobazam and Codeine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clobazam belongs to Central Nervous System; Codeine belongs to Musculoskeletal.
Por que acontece
Additive CNS and respiratory depression, plus possible CYP2D6 inhibition by clobazam.
O que fazer
Avoid or limit to patients with no alternative, using the lowest doses and shortest duration. Monitor for sedation and respiratory depression, and consider naloxone.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Codeine
- Alvimopan + Codeine Contraindicada
- Codeine + Isocarboxazid Contraindicada
- Codeine + Olanzapine / samidorphan Contraindicada
- Codeine + Phenelzine Contraindicada
- Codeine + Tranylcypromine Contraindicada
- Alfentanil + Codeine Grave
Outras interações de Clobazam
- Amobarbital + Clobazam Grave
- Buprenorphine + Clobazam Grave
- Butorphanol + Clobazam Grave
- Carisoprodol + Clobazam Grave
- Chloral hydrate + Clobazam Grave
- Clobazam + Clozapine Grave
Perguntas frequentes
Can I take Clobazam with Codeine?
MediHelp rates the interaction as major. Clobazam and Codeine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzodiazepines combined with opioids carry a boxed warning for profound sedation, respiratory depression, coma and death. Clobazam may also weakly inhibit CYP2D6, which could reduce activation of codeine to morphine.
How serious is the interaction between Clobazam and Codeine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid or limit to patients with no alternative, using the lowest doses and shortest duration. Monitor for sedation and respiratory depression, and consider naloxone.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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