Interações medicamentosas
Caffeine + Selegiline transdermal
Gravidade: Grave
Caffeine and Selegiline transdermal: major interaction.
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Resumo
Selegiline at antidepressant doses causes nonselective MAO inhibition, and combining it with sympathomimetic stimulants such as caffeine may provoke hypertensive reactions. Palpitations, headache and tachycardia may occur, and severe hypertension is possible with high caffeine intake.
O que esta interação significa em palavras simples
Caffeine and Selegiline transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
MAO inhibition combined with caffeine-induced catecholamine release produces additive pressor effects.
O que fazer
Avoid caffeine-containing medicines and limit dietary caffeine in patients on transdermal selegiline. Monitor blood pressure and counsel on symptoms of hypertensive crisis.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Caffeine
- Caffeine + Ephedrine Grave
- Caffeine + Fezolinetant Grave
- Caffeine + Methylenedioxymethamphetamine Grave
- Adenosine + Caffeine Moderada
- Benzphetamine + Caffeine Moderada
- Caffeine + Ciprofloxacin Moderada
Perguntas frequentes
Can I take Caffeine with Selegiline transdermal?
MediHelp rates the interaction as major. Caffeine and Selegiline transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Selegiline at antidepressant doses causes nonselective MAO inhibition, and combining it with sympathomimetic stimulants such as caffeine may provoke hypertensive reactions. Palpitations, headache and tachycardia may occur, and severe hypertension is possible with high caffeine intake.
How serious is the interaction between Caffeine and Selegiline transdermal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid caffeine-containing medicines and limit dietary caffeine in patients on transdermal selegiline. Monitor blood pressure and counsel on symptoms of hypertensive crisis.
What other medicines interact with Caffeine?
MediHelp also lists interactions of Caffeine with, for example, Ephedrine, Fezolinetant, Methylenedioxymethamphetamine. The full list is on the Caffeine page.
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