Drug interactions
Calcifediol + Captopril-hydrochlorothiazide
Severity: Moderate
Calcifediol and Captopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics reduce urinary calcium excretion, and calcifediol increases calcium absorption from the gut. Together they can produce hypercalcemia, which may cause nausea, confusion, arrhythmias and kidney problems.
What this interaction means in plain words
Calcifediol and Captopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcifediol belongs to Musculoskeletal; Captopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Hydrochlorothiazide enhances renal calcium reabsorption while calcifediol (a vitamin D metabolite) increases intestinal calcium absorption, producing additive rises in serum calcium.
What to do
Measure serum calcium at baseline and periodically during combined therapy, especially in patients with renal impairment. Reduce the calcifediol dose or stop the thiazide if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Calcifediol
- Amlodipine-hydrochlorothiazide-valsartan + Calcifediol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcifediol Moderate
- Amobarbital + Calcifediol Moderate
- Atenolol-chlorthalidone + Calcifediol Moderate
- Azilsartan-chlorthalidone + Calcifediol Moderate
- Calcifediol + Candesartan-hydrochlorothiazide Moderate
Frequently asked questions
Can I take Calcifediol with Captopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Calcifediol and Captopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics reduce urinary calcium excretion, and calcifediol increases calcium absorption from the gut. Together they can produce hypercalcemia, which may cause nausea, confusion, arrhythmias and kidney problems.
How serious is the interaction between Calcifediol and Captopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure serum calcium at baseline and periodically during combined therapy, especially in patients with renal impairment. Reduce the calcifediol dose or stop the thiazide if hypercalcemia develops.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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