Interações medicamentosas
Calcium carbonate + Sodium polystyrene sulfonate
Gravidade: Moderada
Calcium carbonate and Sodium polystyrene sulfonate: moderate interaction.
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Resumo
Sodium polystyrene sulfonate can bind calcium in the gut, and the antacid effect of calcium carbonate may be offset by cation exchange. Reduced binding of bicarbonate-producing cations has been associated with metabolic alkalosis, especially in renal impairment. Clinical impact is usually modest but can matter in dialysis patients.
O que esta interação significa em palavras simples
Calcium carbonate and Sodium polystyrene sulfonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Sodium polystyrene sulfonate belongs to Miscellaneous.
Por que acontece
Non-absorbed cation-exchange resin binds calcium and other cations in the gut, and combined with non-absorbable antacid it can leave bicarbonate unneutralized and cause systemic alkalosis.
O que fazer
Separate administration by at least 3 hours (6 hours in gastroparesis) and monitor serum calcium, potassium and acid-base status in renal impairment.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Calcium carbonate
Outras interações de Sodium polystyrene sulfonate
Perguntas frequentes
Can I take Calcium carbonate with Sodium polystyrene sulfonate?
MediHelp rates the interaction as moderate. Calcium carbonate and Sodium polystyrene sulfonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium polystyrene sulfonate can bind calcium in the gut, and the antacid effect of calcium carbonate may be offset by cation exchange. Reduced binding of bicarbonate-producing cations has been associated with metabolic alkalosis, especially in renal impairment. Clinical impact is usually modest but can matter in dialysis patients.
How serious is the interaction between Calcium carbonate and Sodium polystyrene sulfonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate administration by at least 3 hours (6 hours in gastroparesis) and monitor serum calcium, potassium and acid-base status in renal impairment.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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