Interações medicamentosas
Carbamazepine + Isoniazid
Gravidade: Grave
Carbamazepine and Isoniazid: major interaction.
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Resumo
Isoniazid raises carbamazepine concentrations, leading to toxicity such as dizziness, ataxia, diplopia and nausea, and both drugs are hepatotoxic. Carbamazepine may in turn increase the formation of toxic isoniazid metabolites.
O que esta interação significa em palavras simples
Carbamazepine and Isoniazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Isoniazid belongs to Anti Bacterial.
Por que acontece
Isoniazid inhibits CYP3A4 metabolism of carbamazepine, and carbamazepine induction may increase hepatotoxic isoniazid metabolites.
O que fazer
Monitor carbamazepine levels and reduce the dose if needed. Check liver function regularly and watch for signs of hepatotoxicity.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Isoniazid
Outras interações de Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicada
- Cabotegravir + Carbamazepine Contraindicada
- Carbamazepine + Delamanid Contraindicada
- Carbamazepine + Dienogest / estradiol valerate Contraindicada
- Carbamazepine + Doravirine Contraindicada
- Carbamazepine + Elbasvir / grazoprevir Contraindicada
Perguntas frequentes
Can I take Carbamazepine with Isoniazid?
MediHelp rates the interaction as major. Carbamazepine and Isoniazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Isoniazid raises carbamazepine concentrations, leading to toxicity such as dizziness, ataxia, diplopia and nausea, and both drugs are hepatotoxic. Carbamazepine may in turn increase the formation of toxic isoniazid metabolites.
How serious is the interaction between Carbamazepine and Isoniazid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor carbamazepine levels and reduce the dose if needed. Check liver function regularly and watch for signs of hepatotoxicity.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Didanosine. The full list is on the Isoniazid page.
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