Interações medicamentosas
Didanosine + Isoniazid
Gravidade: Grave
Didanosine and Isoniazid: major interaction.
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Resumo
Both drugs can cause peripheral neuropathy, so combined use may increase the incidence or severity of nerve damage. Neuropathy may be dose-limiting and sometimes persists after discontinuation.
O que esta interação significa em palavras simples
Didanosine and Isoniazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Didanosine belongs to Anti Virals; Isoniazid belongs to Anti Bacterial.
Por que acontece
Additive neurotoxicity; isoniazid interferes with pyridoxine function while didanosine causes mitochondrial toxicity in neurons.
O que fazer
Avoid the combination where possible, or give pyridoxine with isoniazid and examine the patient regularly for numbness, tingling or pain. Change therapy if neuropathy develops.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Isoniazid
Outras interações de Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicada
- Didanosine + Hydroxycarbamide Contraindicada
- Didanosine + Hydroxyurea Contraindicada
- Didanosine + Ribavirin Contraindicada
- Didanosine + Stavudine Contraindicada
- Allopurinol + Didanosine Grave
Perguntas frequentes
Can I take Didanosine with Isoniazid?
MediHelp rates the interaction as major. Didanosine and Isoniazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can cause peripheral neuropathy, so combined use may increase the incidence or severity of nerve damage. Neuropathy may be dose-limiting and sometimes persists after discontinuation.
How serious is the interaction between Didanosine and Isoniazid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or give pyridoxine with isoniazid and examine the patient regularly for numbness, tingling or pain. Change therapy if neuropathy develops.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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