Interações medicamentosas
Carbamazepine + Ticlopidine
Gravidade: Grave
Carbamazepine and Ticlopidine: major interaction.
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Resumo
Ticlopidine can inhibit carbamazepine metabolism, raising its levels and causing dizziness, ataxia, diplopia or nausea. Carbamazepine induction may also lower ticlopidine exposure, and both drugs can cause blood dyscrasias.
O que esta interação significa em palavras simples
Carbamazepine and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Ticlopidine belongs to Cardiovascular.
Por que acontece
Ticlopidine inhibits CYP-mediated carbamazepine metabolism, while carbamazepine induces enzymes that may lower ticlopidine levels.
O que fazer
Monitor carbamazepine concentrations and adjust the dose when starting or stopping ticlopidine, and monitor blood counts regularly. Consider an alternative antiplatelet drug.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Ticlopidine
Outras interações de Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicada
- Cabotegravir + Carbamazepine Contraindicada
- Carbamazepine + Delamanid Contraindicada
- Carbamazepine + Dienogest / estradiol valerate Contraindicada
- Carbamazepine + Doravirine Contraindicada
- Carbamazepine + Elbasvir / grazoprevir Contraindicada
Perguntas frequentes
Can I take Carbamazepine with Ticlopidine?
MediHelp rates the interaction as major. Carbamazepine and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ticlopidine can inhibit carbamazepine metabolism, raising its levels and causing dizziness, ataxia, diplopia or nausea. Carbamazepine induction may also lower ticlopidine exposure, and both drugs can cause blood dyscrasias.
How serious is the interaction between Carbamazepine and Ticlopidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor carbamazepine concentrations and adjust the dose when starting or stopping ticlopidine, and monitor blood counts regularly. Consider an alternative antiplatelet drug.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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