Interações medicamentosas
Carmustine + Cimetidine
Gravidade: Grave
Carmustine and Cimetidine: major interaction.
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Resumo
Cimetidine has been reported to increase carmustine-related bone marrow suppression. This may produce deeper or more prolonged leukopenia and thrombocytopenia.
O que esta interação significa em palavras simples
Carmustine and Cimetidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carmustine belongs to Oncology; Cimetidine belongs to Gastrointestinal Tract.
Por que acontece
Cimetidine may reduce hepatic metabolism of carmustine and possibly adds to marrow suppression; the mechanism is not fully established.
O que fazer
Avoid the combination where possible and use famotidine or another acid suppressant instead. If given together, monitor complete blood counts closely.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
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Outras interações de Cimetidine
- Cimetidine + Dofetilide Contraindicada
- Cimetidine + Fezolinetant Contraindicada
- Alfentanil + Cimetidine Grave
- Atazanavir + Cimetidine Grave
- Cimetidine + Citalopram Grave
- Cimetidine + Clozapine Grave
Outras interações de Carmustine
- Carmustine + Pentostatin Contraindicada
- Carmustine + Chlorambucil Grave
- Carmustine + Cyclophosphamide Grave
- Carmustine + Dacarbazine Grave
- Carmustine + Fingolimod Grave
- Carmustine + Lomustine Grave
Perguntas frequentes
Can I take Carmustine with Cimetidine?
MediHelp rates the interaction as major. Carmustine and Cimetidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cimetidine has been reported to increase carmustine-related bone marrow suppression. This may produce deeper or more prolonged leukopenia and thrombocytopenia.
How serious is the interaction between Carmustine and Cimetidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use famotidine or another acid suppressant instead. If given together, monitor complete blood counts closely.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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