Interações medicamentosas
Cimetidine + Clozapine
Gravidade: Grave
Cimetidine and Clozapine: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Cimetidine can increase clozapine levels, with reports of increased sedation, seizures and other toxicity. Clozapine has a narrow therapeutic window, so exposure changes matter.
O que esta interação significa em palavras simples
Cimetidine and Clozapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cimetidine belongs to Gastrointestinal Tract; Clozapine belongs to Central Nervous System.
Por que acontece
Cimetidine inhibits CYP1A2 and CYP3A4 metabolism of clozapine.
O que fazer
Prefer famotidine or another acid suppressant; if cimetidine is used, monitor clozapine levels and for sedation, hypotension and seizures, and reduce the dose as required.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Cimetidine
- Cimetidine + Dofetilide Contraindicada
- Cimetidine + Fezolinetant Contraindicada
- Alfentanil + Cimetidine Grave
- Atazanavir + Cimetidine Grave
- Carmustine + Cimetidine Grave
- Cimetidine + Citalopram Grave
Outras interações de Clozapine
- Clozapine + Deferiprone Contraindicada
- Clozapine + Irinotecan Contraindicada
- Clozapine + Pimozide Contraindicada
- Clozapine + Thioridazine Contraindicada
- Acalabrutinib + Clozapine Grave
- Adagrasib + Clozapine Grave
Perguntas frequentes
Can I take Cimetidine with Clozapine?
MediHelp rates the interaction as major. Cimetidine and Clozapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cimetidine can increase clozapine levels, with reports of increased sedation, seizures and other toxicity. Clozapine has a narrow therapeutic window, so exposure changes matter.
How serious is the interaction between Cimetidine and Clozapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer famotidine or another acid suppressant; if cimetidine is used, monitor clozapine levels and for sedation, hypotension and seizures, and reduce the dose as required.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
