Interações medicamentosas
Carmustine + Pentostatin
Gravidade: Contraindicada
Carmustine and Pentostatin: contraindicated interaction.
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Resumo
Pentostatin combined with carmustine, etoposide and high-dose cyclophosphamide in transplant conditioning regimens led to fatal pulmonary toxicity with pulmonary edema and hypotension. Pentostatin should not be used in this setting.
O que esta interação significa em palavras simples
Carmustine and Pentostatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Carmustine belongs to Oncology; Pentostatin belongs to Oncology.
Por que acontece
Mechanism not established; additive pulmonary and cardiovascular toxicity is suspected.
O que fazer
Do not combine pentostatin with high-dose carmustine-based conditioning regimens. Use another regimen.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Pentostatin
- Etoposide + Pentostatin Contraindicada
- Fludarabine + Pentostatin Contraindicada
- Cyclophosphamide + Pentostatin Grave
- Deferiprone + Pentostatin Grave
- Fingolimod + Pentostatin Grave
- Nelarabine + Pentostatin Grave
Outras interações de Carmustine
Perguntas frequentes
Can I take Carmustine with Pentostatin?
MediHelp rates the interaction as contraindicated. Carmustine and Pentostatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Pentostatin combined with carmustine, etoposide and high-dose cyclophosphamide in transplant conditioning regimens led to fatal pulmonary toxicity with pulmonary edema and hypotension. Pentostatin should not be used in this setting.
How serious is the interaction between Carmustine and Pentostatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine pentostatin with high-dose carmustine-based conditioning regimens. Use another regimen.
What other medicines interact with Pentostatin?
MediHelp also lists interactions of Pentostatin with, for example, Etoposide, Fludarabine, Cyclophosphamide. The full list is on the Pentostatin page.
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