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Interações medicamentosas

Cefalexin + Cholera vaccine

Gravidade: Moderada

Cefalexin and Cholera vaccine: moderate interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

O conteúdo clínico desta página está disponível apenas em inglês.

Resumo

Oral live attenuated cholera vaccine requires viable bacteria to colonize the gut. Systemic antibiotics may kill the vaccine strain and reduce the immune response. Cefalexin activity against Vibrio is limited, so the effect is possibly smaller than with broader agents.

O que esta interação significa em palavras simples

Cefalexin and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Nível de evidência: Low

Por que acontece

Possible antibacterial activity against the live attenuated vaccine strain lowers its viability and immunogenicity.

O que fazer

Follow labeling by avoiding vaccination within 14 days after systemic antibiotics. Delay antibiotic use after vaccination if clinically acceptable.

O que perguntar ao farmacêutico

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Perguntas frequentes

Can I take Cefalexin with Cholera vaccine?

MediHelp rates the interaction as moderate. Cefalexin and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral live attenuated cholera vaccine requires viable bacteria to colonize the gut. Systemic antibiotics may kill the vaccine strain and reduce the immune response. Cefalexin activity against Vibrio is limited, so the effect is possibly smaller than with broader agents.

How serious is the interaction between Cefalexin and Cholera vaccine?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Follow labeling by avoiding vaccination within 14 days after systemic antibiotics. Delay antibiotic use after vaccination if clinically acceptable.

What other medicines interact with Cefalexin?

MediHelp also lists interactions of Cefalexin with, for example, Amikacin, Avelumab, Balstilimab. The full list is on the Cefalexin page.

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