Interações medicamentosas
Cefalexin + Kanamycin
Gravidade: Moderada
Cefalexin and Kanamycin: moderate interaction.
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Resumo
Concurrent use of cefalexin with an aminoglycoside such as kanamycin has been associated with an increased risk of kidney injury in some reports. Aminoglycosides themselves are nephrotoxic and ototoxic, so any added renal impairment can raise drug exposure and toxicity.
O que esta interação significa em palavras simples
Cefalexin and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Por que acontece
Additive nephrotoxic potential, with reduced renal function leading to higher aminoglycoside accumulation and ototoxicity risk.
O que fazer
Monitor serum creatinine and urine output, and measure aminoglycoside levels where applicable. Adjust the kanamycin dose to renal function and report hearing or balance changes promptly.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Cefalexin
- Amikacin + Cefalexin Moderada
- Avelumab + Cefalexin Moderada
- Balstilimab + Cefalexin Moderada
- Bcg vaccine live + Cefalexin Moderada
- Cefalexin + Cholera vaccine Moderada
- Cefalexin + Gentamicin Moderada
Perguntas frequentes
Can I take Cefalexin with Kanamycin?
MediHelp rates the interaction as moderate. Cefalexin and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use of cefalexin with an aminoglycoside such as kanamycin has been associated with an increased risk of kidney injury in some reports. Aminoglycosides themselves are nephrotoxic and ototoxic, so any added renal impairment can raise drug exposure and toxicity.
How serious is the interaction between Cefalexin and Kanamycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output, and measure aminoglycoside levels where applicable. Adjust the kanamycin dose to renal function and report hearing or balance changes promptly.
What other medicines interact with Cefalexin?
MediHelp also lists interactions of Cefalexin with, for example, Amikacin, Avelumab, Balstilimab. The full list is on the Cefalexin page.
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