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Interações medicamentosas

Cefalexin + Gentamicin

Gravidade: Moderada

Cefalexin and Gentamicin: moderate interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

O conteúdo clínico desta página está disponível apenas em inglês.

Resumo

Gentamicin is nephrotoxic and ototoxic, and cephalosporins have been reported to add to renal injury in some patients. Cefalexin is rarely nephrotoxic, so the effect is modest. Risk rises with renal impairment, advanced age, and dehydration.

O que esta interação significa em palavras simples

Cefalexin and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Cefalexin belongs to Anti Bacterial; Gentamicin belongs to Anti Bacterial.

Nível de evidência: Low

Por que acontece

Possible additive nephrotoxicity; mechanism poorly defined.

O que fazer

Monitor serum creatinine and gentamicin levels during therapy. Maintain hydration and avoid additional nephrotoxins.

O que perguntar ao farmacêutico

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Perguntas frequentes

Can I take Cefalexin with Gentamicin?

MediHelp rates the interaction as moderate. Cefalexin and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gentamicin is nephrotoxic and ototoxic, and cephalosporins have been reported to add to renal injury in some patients. Cefalexin is rarely nephrotoxic, so the effect is modest. Risk rises with renal impairment, advanced age, and dehydration.

How serious is the interaction between Cefalexin and Gentamicin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and gentamicin levels during therapy. Maintain hydration and avoid additional nephrotoxins.

What other medicines interact with Cefalexin?

MediHelp also lists interactions of Cefalexin with, for example, Amikacin, Avelumab, Balstilimab. The full list is on the Cefalexin page.

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