Interações medicamentosas
Cefixime + Warfarin
Gravidade: Moderada
Cefixime and Warfarin: moderate interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Cephalosporins can increase the anticoagulant effect of warfarin and raise INR in some patients, increasing the risk of bleeding. Infection itself, reduced food intake and antibiotic effects on gut flora also contribute to this change.
O que esta interação significa em palavras simples
Cefixime and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefixime belongs to Anti Bacterial; Warfarin belongs to Cardiovascular.
Por que acontece
Probably reduced vitamin K availability from gut flora suppression, with the contribution of the acute illness; direct effect on warfarin metabolism is not established.
O que fazer
Check INR within a few days of starting cefixime and again during and after the course. Reduce the warfarin dose if INR rises and watch for bleeding.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Cefixime e Warfarin, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Cefixime
- Cefixime + Typhoid vaccine live Grave
- Cefixime + Cholera vaccine Moderada
- Cefixime + Kanamycin Moderada
- Cefixime + Microbiota Moderada
- Cefixime + Plazomicin Moderada
- Cefixime + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderada
Outras interações de Warfarin
- Defibrotide + Warfarin Contraindicada
- Ketorolac + Warfarin Contraindicada
- Abciximab + Warfarin Grave
- Acetylsalicylic acid + Warfarin Grave
- Adagrasib + Warfarin Grave
- Amiodarone + Warfarin Grave
Perguntas frequentes
Can I take Cefixime with Warfarin?
MediHelp rates the interaction as moderate. Cefixime and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cephalosporins can increase the anticoagulant effect of warfarin and raise INR in some patients, increasing the risk of bleeding. Infection itself, reduced food intake and antibiotic effects on gut flora also contribute to this change.
How serious is the interaction between Cefixime and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR within a few days of starting cefixime and again during and after the course. Reduce the warfarin dose if INR rises and watch for bleeding.
What other medicines interact with Cefixime?
MediHelp also lists interactions of Cefixime with, for example, Typhoid vaccine live, Cholera vaccine, Kanamycin. The full list is on the Cefixime page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
