Interações medicamentosas
Cefixime + Typhoid vaccine live
Gravidade: Grave
Cefixime and Typhoid vaccine live: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Oral live typhoid vaccine depends on viable attenuated Salmonella Typhi replicating in the gut. Cefixime is used to treat typhoid and may reduce vaccine viability and the immune response.
O que esta interação significa em palavras simples
Cefixime and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Antibacterial activity inhibits the live attenuated Salmonella strain, reducing immunogenicity.
O que fazer
Give live oral typhoid vaccine at least 3 days after the last cefixime dose, or vaccinate beforehand. Use the inactivated parenteral vaccine if timing cannot be separated.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Cefixime
- Cefixime + Cholera vaccine Moderada
- Cefixime + Kanamycin Moderada
- Cefixime + Microbiota Moderada
- Cefixime + Plazomicin Moderada
- Cefixime + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderada
- Cefixime + Warfarin Moderada
Perguntas frequentes
Can I take Cefixime with Typhoid vaccine live?
MediHelp rates the interaction as major. Cefixime and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oral live typhoid vaccine depends on viable attenuated Salmonella Typhi replicating in the gut. Cefixime is used to treat typhoid and may reduce vaccine viability and the immune response.
How serious is the interaction between Cefixime and Typhoid vaccine live?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give live oral typhoid vaccine at least 3 days after the last cefixime dose, or vaccinate beforehand. Use the inactivated parenteral vaccine if timing cannot be separated.
What other medicines interact with Cefixime?
MediHelp also lists interactions of Cefixime with, for example, Cholera vaccine, Kanamycin, Microbiota. The full list is on the Cefixime page.
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