Interações medicamentosas
Cefixime + Kanamycin
Gravidade: Moderada
Cefixime and Kanamycin: moderate interaction.
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Resumo
Aminoglycosides such as kanamycin are nephrotoxic and ototoxic, and cephalosporins have occasionally been associated with additive renal injury when given alongside them. Cefixime is itself rarely nephrotoxic and is renally cleared, so reduced renal function may raise exposure to both drugs.
O que esta interação significa em palavras simples
Cefixime and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Por que acontece
Possible additive nephrotoxicity, with impaired renal function reducing clearance of both agents.
O que fazer
Monitor serum creatinine and urine output, and consider kanamycin levels and hearing or vestibular symptoms during therapy. Adjust doses to renal function and keep the patient well hydrated.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Cefixime
- Cefixime + Typhoid vaccine live Grave
- Cefixime + Cholera vaccine Moderada
- Cefixime + Microbiota Moderada
- Cefixime + Plazomicin Moderada
- Cefixime + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderada
- Cefixime + Warfarin Moderada
Perguntas frequentes
Can I take Cefixime with Kanamycin?
MediHelp rates the interaction as moderate. Cefixime and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides such as kanamycin are nephrotoxic and ototoxic, and cephalosporins have occasionally been associated with additive renal injury when given alongside them. Cefixime is itself rarely nephrotoxic and is renally cleared, so reduced renal function may raise exposure to both drugs.
How serious is the interaction between Cefixime and Kanamycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output, and consider kanamycin levels and hearing or vestibular symptoms during therapy. Adjust doses to renal function and keep the patient well hydrated.
What other medicines interact with Cefixime?
MediHelp also lists interactions of Cefixime with, for example, Typhoid vaccine live, Cholera vaccine, Microbiota. The full list is on the Cefixime page.
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