Interações medicamentosas
Cefixime + Plazomicin
Gravidade: Moderada
Cefixime and Plazomicin: moderate interaction.
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Resumo
Plazomicin carries a boxed warning for nephrotoxicity, ototoxicity and neuromuscular blockade. Cefixime is renally cleared and may add to renal burden or accumulate if kidney function declines during plazomicin therapy.
O que esta interação significa em palavras simples
Cefixime and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefixime belongs to Anti Bacterial; Plazomicin belongs to Anti Bacterial.
Por que acontece
Possible additive nephrotoxicity, with reduced renal clearance of both drugs if kidney function falls.
O que fazer
Monitor serum creatinine before and during treatment, and adjust cefixime dosing if creatinine clearance falls. Use plazomicin therapeutic drug monitoring and watch for hearing or balance changes.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Cefixime
- Cefixime + Typhoid vaccine live Grave
- Cefixime + Cholera vaccine Moderada
- Cefixime + Kanamycin Moderada
- Cefixime + Microbiota Moderada
- Cefixime + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderada
- Cefixime + Warfarin Moderada
Outras interações de Plazomicin
- Cefaclor + Plazomicin Moderada
- Cefadroxil + Plazomicin Moderada
- Cefalexin + Plazomicin Moderada
- Cefazolin + Plazomicin Moderada
- Cefditoren + Plazomicin Moderada
- Cefepime + Plazomicin Moderada
Perguntas frequentes
Can I take Cefixime with Plazomicin?
MediHelp rates the interaction as moderate. Cefixime and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Plazomicin carries a boxed warning for nephrotoxicity, ototoxicity and neuromuscular blockade. Cefixime is renally cleared and may add to renal burden or accumulate if kidney function declines during plazomicin therapy.
How serious is the interaction between Cefixime and Plazomicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine before and during treatment, and adjust cefixime dosing if creatinine clearance falls. Use plazomicin therapeutic drug monitoring and watch for hearing or balance changes.
What other medicines interact with Cefixime?
MediHelp also lists interactions of Cefixime with, for example, Typhoid vaccine live, Cholera vaccine, Kanamycin. The full list is on the Cefixime page.
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