Interações medicamentosas
Certolizumab pegol + Smallpox vaccine live
Gravidade: Contraindicada
Certolizumab pegol and Smallpox vaccine live: contraindicated interaction.
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Resumo
Smallpox (vaccinia) vaccine contains replicating live virus that can cause progressive vaccinia in immunosuppressed patients. Certolizumab increases this risk and may reduce vaccine effectiveness.
O que esta interação significa em palavras simples
Certolizumab pegol and Smallpox vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
TNF inhibition impairs cell-mediated control of replicating vaccinia virus.
O que fazer
Avoid vaccinia vaccine during certolizumab therapy unless risk of smallpox exposure clearly outweighs harm. Consider alternative non-replicating vaccines where available.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Certolizumab pegol
- Adenovirus types 4 and 7 live + Certolizumab pegol Contraindicada
- Bcg intravesical live + Certolizumab pegol Contraindicada
- Bcg vaccine live + Certolizumab pegol Contraindicada
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Contraindicada
- Certolizumab pegol + Measles mumps and rubella vaccine Contraindicada
- Certolizumab pegol + Measles mumps and rubella vaccine live Contraindicada
Perguntas frequentes
Can I take Certolizumab pegol with Smallpox vaccine live?
MediHelp rates the interaction as contraindicated. Certolizumab pegol and Smallpox vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Smallpox (vaccinia) vaccine contains replicating live virus that can cause progressive vaccinia in immunosuppressed patients. Certolizumab increases this risk and may reduce vaccine effectiveness.
How serious is the interaction between Certolizumab pegol and Smallpox vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid vaccinia vaccine during certolizumab therapy unless risk of smallpox exposure clearly outweighs harm. Consider alternative non-replicating vaccines where available.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.
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