Interações medicamentosas
Chloramphenicol + Palovarotene
Gravidade: Grave
Chloramphenicol and Palovarotene: major interaction.
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Resumo
Palovarotene is cleared largely by CYP3A4, and chloramphenicol may increase its concentrations. Retinoid toxicity such as mucocutaneous effects, bone changes and hypervitaminosis A-like effects could be amplified.
O que esta interação significa em palavras simples
Chloramphenicol and Palovarotene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Palovarotene belongs to Miscellaneous.
Por que acontece
Chloramphenicol inhibits CYP3A4 metabolism of palovarotene.
O que fazer
Avoid the combination and choose another antibiotic. If it cannot be avoided, monitor closely for retinoid toxicity and consider a dose reduction.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Chloramphenicol
Outras interações de Palovarotene
- Acitretin + Palovarotene Contraindicada
- Isotretinoin + Palovarotene Contraindicada
- Amiodarone + Palovarotene Grave
- Amobarbital + Palovarotene Grave
- Apalutamide + Palovarotene Grave
- Aprepitant + Palovarotene Grave
Perguntas frequentes
Can I take Chloramphenicol with Palovarotene?
MediHelp rates the interaction as major. Chloramphenicol and Palovarotene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Palovarotene is cleared largely by CYP3A4, and chloramphenicol may increase its concentrations. Retinoid toxicity such as mucocutaneous effects, bone changes and hypervitaminosis A-like effects could be amplified.
How serious is the interaction between Chloramphenicol and Palovarotene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose another antibiotic. If it cannot be avoided, monitor closely for retinoid toxicity and consider a dose reduction.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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