Interações medicamentosas
Chlordiazepoxide + Methohexital
Gravidade: Grave
Chlordiazepoxide and Methohexital: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Methohexital is a barbiturate anesthetic; with a benzodiazepine, sedation and respiratory and cardiovascular depression are enhanced. Apnea and hypotension may occur at lower methohexital doses.
O que esta interação significa em palavras simples
Chlordiazepoxide and Methohexital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlordiazepoxide belongs to Central Nervous System; Methohexital belongs to Central Nervous System.
Por que acontece
Additive GABA-A mediated CNS and respiratory depression.
O que fazer
Use only where airway and ventilation can be supported, and titrate methohexital to effect at reduced doses. Continuously monitor oxygenation and ventilation.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Chlordiazepoxide
Outras interações de Methohexital
Perguntas frequentes
Can I take Chlordiazepoxide with Methohexital?
MediHelp rates the interaction as major. Chlordiazepoxide and Methohexital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methohexital is a barbiturate anesthetic; with a benzodiazepine, sedation and respiratory and cardiovascular depression are enhanced. Apnea and hypotension may occur at lower methohexital doses.
How serious is the interaction between Chlordiazepoxide and Methohexital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only where airway and ventilation can be supported, and titrate methohexital to effect at reduced doses. Continuously monitor oxygenation and ventilation.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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