Interações medicamentosas
Chlorpromazine + Glycopyrrolate
Gravidade: Moderada
Chlorpromazine and Glycopyrrolate: moderate interaction.
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Resumo
Chlorpromazine has anticholinergic properties that add to those of glycopyrrolate. This may cause dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion, and in severe cases reduced gut motility or ileus.
O que esta interação significa em palavras simples
Chlorpromazine and Glycopyrrolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Glycopyrrolate belongs to Respiratory.
Por que acontece
Additive antimuscarinic (anticholinergic) pharmacodynamic effects.
O que fazer
Monitor for anticholinergic adverse effects, especially in older patients, and for constipation or urinary retention. Reduce the dose of one agent or choose an alternative if symptoms become troublesome.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicada
- Chlorpromazine + Dronedarone Contraindicada
- Chlorpromazine + Droperidol Contraindicada
- Chlorpromazine + Ibutilide Contraindicada
- Chlorpromazine + Metrizamide Contraindicada
- Chlorpromazine + Panobinostat Contraindicada
Outras interações de Glycopyrrolate
- Glycopyrrolate + Potassium chloride Grave
- Amitriptyline + Glycopyrrolate Moderada
- Atropine + Glycopyrrolate Moderada
- Bethanechol + Glycopyrrolate Moderada
- Clomipramine + Glycopyrrolate Moderada
- Clozapine + Glycopyrrolate Moderada
Perguntas frequentes
Can I take Chlorpromazine with Glycopyrrolate?
MediHelp rates the interaction as moderate. Chlorpromazine and Glycopyrrolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine has anticholinergic properties that add to those of glycopyrrolate. This may cause dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion, and in severe cases reduced gut motility or ileus.
How serious is the interaction between Chlorpromazine and Glycopyrrolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects, especially in older patients, and for constipation or urinary retention. Reduce the dose of one agent or choose an alternative if symptoms become troublesome.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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