Interações medicamentosas
Amitriptyline + Glycopyrrolate
Gravidade: Moderada
Amitriptyline and Glycopyrrolate: moderate interaction.
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Resumo
Both drugs have anticholinergic activity, so combined use can cause dry mouth, constipation, urinary retention, blurred vision and tachycardia. In susceptible patients, such as older adults, confusion, ileus or heat intolerance may occur.
O que esta interação significa em palavras simples
Amitriptyline and Glycopyrrolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Glycopyrrolate belongs to Respiratory.
Por que acontece
Additive antimuscarinic effects from muscarinic receptor blockade.
O que fazer
Monitor for anticholinergic toxicity, especially in older patients or those with glaucoma, urinary retention or constipation. Reduce doses or select non-anticholinergic alternatives if effects are troublesome.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicada
- Amitriptyline + Methylene blue Contraindicada
- Amitriptyline + Phenelzine Contraindicada
- Amitriptyline + Pimozide Contraindicada
- Amitriptyline + Procarbazine Contraindicada
- Amitriptyline + Safinamide Contraindicada
Outras interações de Glycopyrrolate
- Glycopyrrolate + Potassium chloride Grave
- Atropine + Glycopyrrolate Moderada
- Bethanechol + Glycopyrrolate Moderada
- Chlorpromazine + Glycopyrrolate Moderada
- Clomipramine + Glycopyrrolate Moderada
- Clozapine + Glycopyrrolate Moderada
Perguntas frequentes
Can I take Amitriptyline with Glycopyrrolate?
MediHelp rates the interaction as moderate. Amitriptyline and Glycopyrrolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have anticholinergic activity, so combined use can cause dry mouth, constipation, urinary retention, blurred vision and tachycardia. In susceptible patients, such as older adults, confusion, ileus or heat intolerance may occur.
How serious is the interaction between Amitriptyline and Glycopyrrolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, especially in older patients or those with glaucoma, urinary retention or constipation. Reduce doses or select non-anticholinergic alternatives if effects are troublesome.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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