Interações medicamentosas
Clomipramine + Glycopyrrolate
Gravidade: Moderada
Clomipramine and Glycopyrrolate: moderate interaction.
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Resumo
Both drugs have anticholinergic activity, so combined use may worsen dry mouth, constipation, urinary retention, blurred vision and tachycardia. Anticholinergic burden is especially important in older patients.
O que esta interação significa em palavras simples
Clomipramine and Glycopyrrolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Glycopyrrolate belongs to Respiratory.
Por que acontece
Additive antimuscarinic effects at peripheral and central cholinergic receptors.
O que fazer
Monitor for anticholinergic effects such as urinary retention, ileus and heat intolerance. Reduce the dose of one drug or choose an alternative if effects are troublesome.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Clomipramine
- Arsenic trioxide + Clomipramine Contraindicada
- Clomipramine + Dofetilide Contraindicada
- Clomipramine + Droperidol Contraindicada
- Clomipramine + Isocarboxazid Contraindicada
- Clomipramine + Methylene blue Contraindicada
- Clomipramine + Pentamidine Contraindicada
Outras interações de Glycopyrrolate
- Glycopyrrolate + Potassium chloride Grave
- Amitriptyline + Glycopyrrolate Moderada
- Atropine + Glycopyrrolate Moderada
- Bethanechol + Glycopyrrolate Moderada
- Chlorpromazine + Glycopyrrolate Moderada
- Clozapine + Glycopyrrolate Moderada
Perguntas frequentes
Can I take Clomipramine with Glycopyrrolate?
MediHelp rates the interaction as moderate. Clomipramine and Glycopyrrolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have anticholinergic activity, so combined use may worsen dry mouth, constipation, urinary retention, blurred vision and tachycardia. Anticholinergic burden is especially important in older patients.
How serious is the interaction between Clomipramine and Glycopyrrolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as urinary retention, ileus and heat intolerance. Reduce the dose of one drug or choose an alternative if effects are troublesome.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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