Interações medicamentosas
Chlorpropamide + Sulphasalazine
Gravidade: Moderada
Chlorpropamide and Sulphasalazine: moderate interaction.
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Resumo
Sulfasalazine contains a sulfonamide-type moiety, and sulfonamide antibacterials are known to potentiate sulfonylurea hypoglycemia. Reports with sulfasalazine are sparse, but an enhanced glucose-lowering effect of chlorpropamide is plausible, and chlorpropamide's long half-life makes prolonged hypoglycemia a concern.
O que esta interação significa em palavras simples
Chlorpropamide and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Sulphasalazine belongs to Gastrointestinal Tract.
Por que acontece
Possible displacement from plasma protein binding and/or reduced sulfonylurea clearance; the mechanism is not well established for sulfasalazine.
O que fazer
Monitor blood glucose more frequently when sulfasalazine is started or stopped in patients on chlorpropamide. Reduce the sulfonylurea dose if hypoglycemia occurs and counsel the patient on its symptoms.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Sulphasalazine
- Deferiprone + Sulphasalazine Grave
- Pexidartinib + Sulphasalazine Grave
- Sepiapterin + Sulphasalazine Grave
- Acalabrutinib + Sulphasalazine Moderada
- Aceclofenac + Sulphasalazine Moderada
- Acetazolamide + Sulphasalazine Moderada
Outras interações de Chlorpropamide
Perguntas frequentes
Can I take Chlorpropamide with Sulphasalazine?
MediHelp rates the interaction as moderate. Chlorpropamide and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfasalazine contains a sulfonamide-type moiety, and sulfonamide antibacterials are known to potentiate sulfonylurea hypoglycemia. Reports with sulfasalazine are sparse, but an enhanced glucose-lowering effect of chlorpropamide is plausible, and chlorpropamide's long half-life makes prolonged hypoglycemia a concern.
How serious is the interaction between Chlorpropamide and Sulphasalazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when sulfasalazine is started or stopped in patients on chlorpropamide. Reduce the sulfonylurea dose if hypoglycemia occurs and counsel the patient on its symptoms.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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