Interações medicamentosas
Ciprofloxacin + Theophylline
Gravidade: Grave
Ciprofloxacin and Theophylline: major interaction.
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Ciprofloxacin reduces theophylline clearance and can raise serum theophylline concentrations substantially in some patients. This can lead to nausea, tachycardia, arrhythmias and seizures. Elderly patients, those with high baseline levels, liver disease or heart failure, and smokers who stop are at greater risk.
O que esta interação significa em palavras simples
Ciprofloxacin and Theophylline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ciprofloxacin belongs to Anti Bacterial; Theophylline belongs to Respiratory.
Por que acontece
Ciprofloxacin inhibits CYP1A2, the main enzyme metabolising theophylline, decreasing its clearance.
O que fazer
Prefer an antibiotic that does not inhibit CYP1A2. If ciprofloxacin is needed, measure theophylline levels before and during therapy and reduce the theophylline dose empirically.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Theophylline
- Riociguat + Theophylline Contraindicada
- Adenosine + Theophylline Grave
- Apalutamide + Theophylline Grave
- Bupropion + Theophylline Grave
- Carvedilol + Theophylline Grave
- Cimetidine + Theophylline Grave
Outras interações de Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicada
- Ciprofloxacin + Fezolinetant Contraindicada
- Ciprofloxacin + Thioridazine Contraindicada
- Ciprofloxacin + Tizanidine Contraindicada
- Ciprofloxacin + Vandetanib Contraindicada
- Alosetron + Ciprofloxacin Grave
Perguntas frequentes
Can I take Ciprofloxacin with Theophylline?
MediHelp rates the interaction as major. Ciprofloxacin and Theophylline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ciprofloxacin reduces theophylline clearance and can raise serum theophylline concentrations substantially in some patients. This can lead to nausea, tachycardia, arrhythmias and seizures. Elderly patients, those with high baseline levels, liver disease or heart failure, and smokers who stop are at greater risk.
How serious is the interaction between Ciprofloxacin and Theophylline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antibiotic that does not inhibit CYP1A2. If ciprofloxacin is needed, measure theophylline levels before and during therapy and reduce the theophylline dose empirically.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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