Interações medicamentosas
Riociguat + Theophylline
Gravidade: Contraindicada
Riociguat and Theophylline: contraindicated interaction.
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Riociguat is contraindicated with PDE inhibitors including nonspecific ones such as theophylline and dipyridamole. Combining them can cause additive vasodilation with symptomatic hypotension through increased cGMP signalling.
O que esta interação significa em palavras simples
Riociguat and Theophylline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Riociguat belongs to Cardiovascular; Theophylline belongs to Respiratory.
Por que acontece
Additive increases in cGMP: riociguat stimulates soluble guanylate cyclase while theophylline inhibits phosphodiesterases.
O que fazer
Do not use together. Choose an alternative bronchodilator, or if theophylline is essential discuss options with the specialist and avoid riociguat.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Referências
- Adempas - FDA drug label (DailyMed) — openFDA / DailyMed
Outras interações de Theophylline
Outras interações de Riociguat
- Avanafil + Riociguat Contraindicada
- Dipyridamole + Riociguat Contraindicada
- Isosorbide dinitrate + Riociguat Contraindicada
- Isosorbide mononitrate + Riociguat Contraindicada
- Nitroglycerin + Riociguat Contraindicada
- Riociguat + Sildenafil Contraindicada
Perguntas frequentes
Can I take Riociguat with Theophylline?
MediHelp rates the interaction as contraindicated. Riociguat and Theophylline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Riociguat is contraindicated with PDE inhibitors including nonspecific ones such as theophylline and dipyridamole. Combining them can cause additive vasodilation with symptomatic hypotension through increased cGMP signalling.
How serious is the interaction between Riociguat and Theophylline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Choose an alternative bronchodilator, or if theophylline is essential discuss options with the specialist and avoid riociguat.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Adenosine, Apalutamide, Bupropion. The full list is on the Theophylline page.
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