Interações medicamentosas
Clotrimazole + Entrectinib
Gravidade: Moderada
Clotrimazole and Entrectinib: moderate interaction.
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Resumo
Clotrimazole may increase entrectinib concentrations when systemically absorbed, raising the risk of QT prolongation, heart failure and other dose-related toxicities.
O que esta interação significa em palavras simples
Clotrimazole and Entrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clotrimazole belongs to Anti Fungals; Entrectinib belongs to Oncology.
Por que acontece
Clotrimazole inhibits CYP3A4, the main metabolic pathway of entrectinib.
O que fazer
Use topical forms or alternative antifungals where possible. If a CYP3A4 inhibitor is needed, reduce the entrectinib dose per labeling and monitor ECG.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Clotrimazole
- Clotrimazole + Lomitapide Grave
- Clotrimazole + Mavacamten Grave
- Clotrimazole + Mobocertinib Grave
- Clotrimazole + Voclosporin Grave
- Bosutinib + Clotrimazole Moderada
- Cannabidiol + Clotrimazole Moderada
Outras interações de Entrectinib
Perguntas frequentes
Can I take Clotrimazole with Entrectinib?
MediHelp rates the interaction as moderate. Clotrimazole and Entrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clotrimazole may increase entrectinib concentrations when systemically absorbed, raising the risk of QT prolongation, heart failure and other dose-related toxicities.
How serious is the interaction between Clotrimazole and Entrectinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use topical forms or alternative antifungals where possible. If a CYP3A4 inhibitor is needed, reduce the entrectinib dose per labeling and monitor ECG.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Lomitapide, Mavacamten, Mobocertinib. The full list is on the Clotrimazole page.
Monografias completas, posologia e verificador de interações no app MediHelp
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