Interações medicamentosas
Clozapine + Scopolamine
Gravidade: Grave
Clozapine and Scopolamine: major interaction.
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Resumo
Clozapine is strongly anticholinergic, and scopolamine adds to this burden. The combination raises the risk of constipation that can progress to ileus, urinary retention, delirium and tachycardia, and sedation is additive.
O que esta interação significa em palavras simples
Clozapine and Scopolamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clozapine belongs to Central Nervous System; Scopolamine belongs to Respiratory.
Por que acontece
Additive muscarinic receptor blockade with reduced gastrointestinal motility, plus additive sedation.
O que fazer
Avoid the combination where possible, and if used monitor bowel function closely and for delirium and urinary retention. Treat constipation early and reconsider scopolamine if gut hypomotility appears.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Scopolamine
Outras interações de Clozapine
- Clozapine + Deferiprone Contraindicada
- Clozapine + Irinotecan Contraindicada
- Clozapine + Pimozide Contraindicada
- Clozapine + Thioridazine Contraindicada
- Acalabrutinib + Clozapine Grave
- Adagrasib + Clozapine Grave
Perguntas frequentes
Can I take Clozapine with Scopolamine?
MediHelp rates the interaction as major. Clozapine and Scopolamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clozapine is strongly anticholinergic, and scopolamine adds to this burden. The combination raises the risk of constipation that can progress to ileus, urinary retention, delirium and tachycardia, and sedation is additive.
How serious is the interaction between Clozapine and Scopolamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, and if used monitor bowel function closely and for delirium and urinary retention. Treat constipation early and reconsider scopolamine if gut hypomotility appears.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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