Interações medicamentosas
Cocaine + Dextroamphetamine
Gravidade: Grave
Cocaine and Dextroamphetamine: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Both drugs increase synaptic monoamines and have sympathomimetic effects. Combined use can increase blood pressure and heart rate and the risk of arrhythmia, and systemic absorption from topical medical cocaine is limited but can be significant on mucosal surfaces. Illicit or high-dose cocaine use would carry a greater risk.
O que esta interação significa em palavras simples
Cocaine and Dextroamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cocaine belongs to Central Nervous System; Dextroamphetamine belongs to Central Nervous System.
Por que acontece
Additive monoamine reuptake inhibition (cocaine) and release (amphetamine), producing sympathomimetic and serotonergic effects.
O que fazer
Avoid using cocaine in patients taking dextroamphetamine where alternative anesthetics exist. If it is used, monitor blood pressure, heart rate and ECG and limit the dose.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicada
- Dextroamphetamine + Linezolid Contraindicada
- Dextroamphetamine + Methylene blue Contraindicada
- Dextroamphetamine + Phenelzine Contraindicada
- Dextroamphetamine + Rasagiline Contraindicada
- Dextroamphetamine + Safinamide Contraindicada
Outras interações de Cocaine
- Cocaine + Isocarboxazid Contraindicada
- Cocaine + Phenelzine Contraindicada
- Cocaine + Procarbazine Contraindicada
- Amitriptyline + Cocaine Grave
- Bisoprolol + Cocaine Grave
- Citalopram + Cocaine Grave
Perguntas frequentes
Can I take Cocaine with Dextroamphetamine?
MediHelp rates the interaction as major. Cocaine and Dextroamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs increase synaptic monoamines and have sympathomimetic effects. Combined use can increase blood pressure and heart rate and the risk of arrhythmia, and systemic absorption from topical medical cocaine is limited but can be significant on mucosal surfaces. Illicit or high-dose cocaine use would carry a greater risk.
How serious is the interaction between Cocaine and Dextroamphetamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using cocaine in patients taking dextroamphetamine where alternative anesthetics exist. If it is used, monitor blood pressure, heart rate and ECG and limit the dose.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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