Interações medicamentosas
Cocaine + Duloxetine
Gravidade: Grave
Cocaine and Duloxetine: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Cocaine blocks reuptake of serotonin, norepinephrine and dopamine, so systemic cocaine use with duloxetine may increase serotonin toxicity and cardiovascular stimulation. Topical medical cocaine has little systemic absorption, so the risk is mostly with illicit or high-dose use.
O que esta interação significa em palavras simples
Cocaine and Duloxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cocaine belongs to Central Nervous System; Duloxetine belongs to Central Nervous System.
Por que acontece
Additive monoamine reuptake inhibition causing serotonergic and sympathomimetic effects.
O que fazer
Counsel patients to avoid cocaine use and monitor for serotonin syndrome, hypertension and tachycardia if exposure occurs. For topical use, limit dose to the minimum needed.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Cocaine e Duloxetine, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 7 dias na web. Sem cartão.
Outras interações de Duloxetine
- Duloxetine + Isocarboxazid Contraindicada
- Duloxetine + Linezolid Contraindicada
- Duloxetine + Methylene blue Contraindicada
- Duloxetine + Phenelzine Contraindicada
- Duloxetine + Procarbazine Contraindicada
- Duloxetine + Rasagiline Contraindicada
Outras interações de Cocaine
- Cocaine + Isocarboxazid Contraindicada
- Cocaine + Phenelzine Contraindicada
- Cocaine + Procarbazine Contraindicada
- Amitriptyline + Cocaine Grave
- Bisoprolol + Cocaine Grave
- Citalopram + Cocaine Grave
Perguntas frequentes
Can I take Cocaine with Duloxetine?
MediHelp rates the interaction as major. Cocaine and Duloxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cocaine blocks reuptake of serotonin, norepinephrine and dopamine, so systemic cocaine use with duloxetine may increase serotonin toxicity and cardiovascular stimulation. Topical medical cocaine has little systemic absorption, so the risk is mostly with illicit or high-dose use.
How serious is the interaction between Cocaine and Duloxetine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid cocaine use and monitor for serotonin syndrome, hypertension and tachycardia if exposure occurs. For topical use, limit dose to the minimum needed.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
