Interações medicamentosas
Colchicine + Erdafitinib
Gravidade: Grave
Colchicine and Erdafitinib: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Erdafitinib inhibits P-glycoprotein and may increase colchicine exposure. Colchicine has a narrow therapeutic index, so higher levels may cause serious toxicity.
O que esta interação significa em palavras simples
Colchicine and Erdafitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Colchicine belongs to Genitourinary; Erdafitinib belongs to Oncology.
Por que acontece
P-gp inhibition by erdafitinib reduces colchicine efflux and clearance.
O que fazer
If unavoidable, separate colchicine from erdafitinib by at least 6 hours, consider reducing the colchicine dose, and monitor for toxicity.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Colchicine
- Clarithromycin + Colchicine Contraindicada
- Cobicistat + Colchicine Contraindicada
- Colchicine + Cyclosporine Contraindicada
- Colchicine + Ensitrelvir Contraindicada
- Colchicine + Levoketoconazole Contraindicada
- Colchicine + Nirmatrelvir Contraindicada
Outras interações de Erdafitinib
Perguntas frequentes
Can I take Colchicine with Erdafitinib?
MediHelp rates the interaction as major. Colchicine and Erdafitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erdafitinib inhibits P-glycoprotein and may increase colchicine exposure. Colchicine has a narrow therapeutic index, so higher levels may cause serious toxicity.
How serious is the interaction between Colchicine and Erdafitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If unavoidable, separate colchicine from erdafitinib by at least 6 hours, consider reducing the colchicine dose, and monitor for toxicity.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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