Interações medicamentosas
Chloramphenicol + Erdafitinib
Gravidade: Grave
Chloramphenicol and Erdafitinib: major interaction.
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Resumo
Erdafitinib is metabolized by CYP2C9 and CYP3A4, and inhibition of these pathways can raise its exposure. This may increase hyperphosphatemia, ocular and dermatologic toxicity, and stomatitis.
O que esta interação significa em palavras simples
Chloramphenicol and Erdafitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Erdafitinib belongs to Oncology.
Por que acontece
Chloramphenicol inhibits CYP3A4 and CYP2C9, reducing erdafitinib clearance.
O que fazer
Use an alternative antibiotic if possible. If coadministered, monitor closely for adverse reactions and consider reducing the erdafitinib dose, and re-escalate after the inhibitor is stopped if no toxicity.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Chloramphenicol
Outras interações de Erdafitinib
Perguntas frequentes
Can I take Chloramphenicol with Erdafitinib?
MediHelp rates the interaction as major. Chloramphenicol and Erdafitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erdafitinib is metabolized by CYP2C9 and CYP3A4, and inhibition of these pathways can raise its exposure. This may increase hyperphosphatemia, ocular and dermatologic toxicity, and stomatitis.
How serious is the interaction between Chloramphenicol and Erdafitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic if possible. If coadministered, monitor closely for adverse reactions and consider reducing the erdafitinib dose, and re-escalate after the inhibitor is stopped if no toxicity.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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