Interações medicamentosas
Colchicine + Letermovir
Gravidade: Grave
Colchicine and Letermovir: major interaction.
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Resumo
Letermovir inhibits CYP3A4 moderately and may raise colchicine concentrations. This increases the risk of colchicine toxicity such as myopathy, diarrhea and cytopenias.
O que esta interação significa em palavras simples
Colchicine and Letermovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Colchicine belongs to Genitourinary; Letermovir belongs to Anti Virals.
Por que acontece
Letermovir inhibits CYP3A4 (and transporters), reducing colchicine elimination.
O que fazer
Reduce the colchicine dose and monitor for signs of toxicity. Avoid the combination in patients with renal or hepatic impairment.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Colchicine
- Clarithromycin + Colchicine Contraindicada
- Cobicistat + Colchicine Contraindicada
- Colchicine + Cyclosporine Contraindicada
- Colchicine + Ensitrelvir Contraindicada
- Colchicine + Levoketoconazole Contraindicada
- Colchicine + Nirmatrelvir Contraindicada
Outras interações de Letermovir
- Ergotamine + Letermovir Contraindicada
- Letermovir + Pimozide Contraindicada
- Apalutamide + Letermovir Grave
- Atorvastatin + Letermovir Grave
- Carbamazepine + Letermovir Grave
- Cyclosporin + Letermovir Grave
Perguntas frequentes
Can I take Colchicine with Letermovir?
MediHelp rates the interaction as major. Colchicine and Letermovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Letermovir inhibits CYP3A4 moderately and may raise colchicine concentrations. This increases the risk of colchicine toxicity such as myopathy, diarrhea and cytopenias.
How serious is the interaction between Colchicine and Letermovir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the colchicine dose and monitor for signs of toxicity. Avoid the combination in patients with renal or hepatic impairment.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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