Interações medicamentosas
Ergotamine + Letermovir
Gravidade: Contraindicada
Ergotamine and Letermovir: contraindicated interaction.
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Resumo
Letermovir can raise ergotamine exposure by inhibiting its CYP3A-mediated clearance. Higher ergotamine levels increase the risk of ergotism, with severe peripheral vasospasm and tissue ischemia.
O que esta interação significa em palavras simples
Ergotamine and Letermovir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ergotamine belongs to Central Nervous System; Letermovir belongs to Anti Virals.
Por que acontece
Letermovir inhibits CYP3A4, reducing the metabolism of ergotamine.
O que fazer
Do not co-administer ergot alkaloids with letermovir; use a non-ergot agent for migraine during letermovir therapy.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Ergotamine
- Almotriptan + Ergotamine Contraindicada
- Atazanavir + Ergotamine Contraindicada
- Clarithromycin + Ergotamine Contraindicada
- Cobicistat + Ergotamine Contraindicada
- Darunavir + Ergotamine Contraindicada
- Dihydroergotamine intranasal + Ergotamine Contraindicada
Outras interações de Letermovir
- Letermovir + Pimozide Contraindicada
- Apalutamide + Letermovir Grave
- Atorvastatin + Letermovir Grave
- Carbamazepine + Letermovir Grave
- Colchicine + Letermovir Grave
- Cyclosporin + Letermovir Grave
Perguntas frequentes
Can I take Ergotamine with Letermovir?
MediHelp rates the interaction as contraindicated. Ergotamine and Letermovir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Letermovir can raise ergotamine exposure by inhibiting its CYP3A-mediated clearance. Higher ergotamine levels increase the risk of ergotism, with severe peripheral vasospasm and tissue ischemia.
How serious is the interaction between Ergotamine and Letermovir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer ergot alkaloids with letermovir; use a non-ergot agent for migraine during letermovir therapy.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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