Interações medicamentosas
Conivaptan + Posaconazole
Gravidade: Contraindicada
Conivaptan and Posaconazole: contraindicated interaction.
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Resumo
Posaconazole increases conivaptan exposure, raising the risk of overly rapid serum sodium correction and osmotic demyelination, as well as hypotension.
O que esta interação significa em palavras simples
Conivaptan and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Strong CYP3A4 inhibition decreases conivaptan metabolism.
O que fazer
Do not co-administer, per conivaptan labeling. Use an alternative treatment for hyponatremia and monitor serum sodium closely.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Posaconazole
- Artemether + Posaconazole Contraindicada
- Avanafil + Posaconazole Contraindicada
- Cobimetinib + Posaconazole Contraindicada
- Dihydroergotamine intranasal + Posaconazole Contraindicada
- Dihydroergotamine + Posaconazole Contraindicada
- Dronedarone + Posaconazole Contraindicada
Perguntas frequentes
Can I take Conivaptan with Posaconazole?
MediHelp rates the interaction as contraindicated. Conivaptan and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Posaconazole increases conivaptan exposure, raising the risk of overly rapid serum sodium correction and osmotic demyelination, as well as hypotension.
How serious is the interaction between Conivaptan and Posaconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer, per conivaptan labeling. Use an alternative treatment for hyponatremia and monitor serum sodium closely.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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