Interações medicamentosas
Dihydroergotamine + Posaconazole
Gravidade: Contraindicada
Dihydroergotamine and Posaconazole: contraindicated interaction.
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Resumo
Posaconazole markedly raises dihydroergotamine exposure. This can cause ergotism with severe peripheral and cerebral vasospasm and ischemia of the limbs, bowel or brain.
O que esta interação significa em palavras simples
Dihydroergotamine and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dihydroergotamine belongs to Central Nervous System; Posaconazole belongs to Anti Fungals.
Por que acontece
Posaconazole strongly inhibits CYP3A4, the main metabolic pathway of dihydroergotamine.
O que fazer
Do not co-administer; this is a labeled contraindication. Use a non-ergot migraine treatment while on posaconazole.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Posaconazole
- Artemether + Posaconazole Contraindicada
- Avanafil + Posaconazole Contraindicada
- Cobimetinib + Posaconazole Contraindicada
- Conivaptan + Posaconazole Contraindicada
- Dihydroergotamine intranasal + Posaconazole Contraindicada
- Dronedarone + Posaconazole Contraindicada
Outras interações de Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicada
- Clarithromycin + Dihydroergotamine Contraindicada
- Dihydroergotamine + Dopamine Contraindicada
- Dihydroergotamine + Dronedarone Contraindicada
- Dihydroergotamine + Efavirenz Contraindicada
- Dihydroergotamine + Eletriptan Contraindicada
Perguntas frequentes
Can I take Dihydroergotamine with Posaconazole?
MediHelp rates the interaction as contraindicated. Dihydroergotamine and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Posaconazole markedly raises dihydroergotamine exposure. This can cause ergotism with severe peripheral and cerebral vasospasm and ischemia of the limbs, bowel or brain.
How serious is the interaction between Dihydroergotamine and Posaconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; this is a labeled contraindication. Use a non-ergot migraine treatment while on posaconazole.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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