Drug interactions
Conivaptan + Posaconazole
Severity: Contraindicated
Conivaptan and Posaconazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole increases conivaptan exposure, raising the risk of overly rapid serum sodium correction and osmotic demyelination, as well as hypotension.
What this interaction means in plain words
Conivaptan and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Strong CYP3A4 inhibition decreases conivaptan metabolism.
What to do
Do not co-administer, per conivaptan labeling. Use an alternative treatment for hyponatremia and monitor serum sodium closely.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
- Dronedarone + Posaconazole Contraindicated
Frequently asked questions
Can I take Conivaptan with Posaconazole?
MediHelp rates the interaction as contraindicated. Conivaptan and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Posaconazole increases conivaptan exposure, raising the risk of overly rapid serum sodium correction and osmotic demyelination, as well as hypotension.
How serious is the interaction between Conivaptan and Posaconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer, per conivaptan labeling. Use an alternative treatment for hyponatremia and monitor serum sodium closely.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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