Interações medicamentosas
Cyclosporin + Fluvastatin
Gravidade: Grave
Cyclosporin and Fluvastatin: major interaction.
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Resumo
Cyclosporine raises fluvastatin exposure and increases the risk of myopathy and rhabdomyolysis. The effect is dose related.
O que esta interação significa em palavras simples
Cyclosporin and Fluvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Fluvastatin belongs to Cardiovascular.
Por que acontece
Cyclosporine inhibits hepatic uptake (OATP1B1) and possibly CYP2C9-mediated clearance of fluvastatin, increasing systemic levels.
O que fazer
Limit fluvastatin to 20 mg twice daily at most, or choose another lipid-lowering approach. Counsel patients to report unexplained muscle pain or weakness and check creatine kinase if symptoms occur.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicada
- Aliskiren + Cyclosporin Contraindicada
- Bcg vaccine live + Cyclosporin Contraindicada
- Bosentan + Cyclosporin Contraindicada
- Cidofovir + Cyclosporin Contraindicada
- Cyclosporin + Dengue vaccine Contraindicada
Outras interações de Fluvastatin
- Cyclosporine + Fluvastatin Grave
- Fluvastatin + Gemfibrozil Grave
- Fluvastatin + Letermovir Grave
- Fluvastatin + Red yeast rice Grave
- Apalutamide + Fluvastatin Moderada
- Cholestyramine + Fluvastatin Moderada
Perguntas frequentes
Can I take Cyclosporin with Fluvastatin?
MediHelp rates the interaction as major. Cyclosporin and Fluvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine raises fluvastatin exposure and increases the risk of myopathy and rhabdomyolysis. The effect is dose related.
How serious is the interaction between Cyclosporin and Fluvastatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit fluvastatin to 20 mg twice daily at most, or choose another lipid-lowering approach. Counsel patients to report unexplained muscle pain or weakness and check creatine kinase if symptoms occur.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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