Interações medicamentosas
Fluvastatin + Letermovir
Gravidade: Grave
Fluvastatin and Letermovir: major interaction.
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Resumo
Letermovir inhibits OATP1B1/3 and raises exposure of many statins, and fluvastatin concentrations may also increase. This raises the risk of myopathy and rhabdomyolysis, and use is not recommended when cyclosporine is also given.
O que esta interação significa em palavras simples
Fluvastatin and Letermovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluvastatin belongs to Cardiovascular; Letermovir belongs to Anti Virals.
Por que acontece
Letermovir inhibits OATP1B1/3 hepatic uptake and possibly BCRP, increasing fluvastatin exposure.
O que fazer
Consider reducing the fluvastatin dose and monitor closely for muscle symptoms. Avoid fluvastatin if the patient also receives cyclosporine.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Fluvastatin
- Cyclosporine + Fluvastatin Grave
- Cyclosporin + Fluvastatin Grave
- Fluvastatin + Gemfibrozil Grave
- Fluvastatin + Red yeast rice Grave
- Apalutamide + Fluvastatin Moderada
- Cholestyramine + Fluvastatin Moderada
Outras interações de Letermovir
- Ergotamine + Letermovir Contraindicada
- Letermovir + Pimozide Contraindicada
- Apalutamide + Letermovir Grave
- Atorvastatin + Letermovir Grave
- Carbamazepine + Letermovir Grave
- Colchicine + Letermovir Grave
Perguntas frequentes
Can I take Fluvastatin with Letermovir?
MediHelp rates the interaction as major. Fluvastatin and Letermovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Letermovir inhibits OATP1B1/3 and raises exposure of many statins, and fluvastatin concentrations may also increase. This raises the risk of myopathy and rhabdomyolysis, and use is not recommended when cyclosporine is also given.
How serious is the interaction between Fluvastatin and Letermovir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the fluvastatin dose and monitor closely for muscle symptoms. Avoid fluvastatin if the patient also receives cyclosporine.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Fluvastatin page.
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