Interações medicamentosas
Fluvastatin + Gemfibrozil
Gravidade: Grave
Fluvastatin and Gemfibrozil: major interaction.
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Resumo
Gemfibrozil inhibits OATP1B1 and glucuronidation and fibrates also have intrinsic myotoxicity, which can raise statin exposure. Fluvastatin is mainly cleared by CYP2C9, so the pharmacokinetic rise is smaller than for other statins, but myopathy and rhabdomyolysis remain possible.
O que esta interação significa em palavras simples
Fluvastatin and Gemfibrozil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluvastatin belongs to Cardiovascular; Gemfibrozil belongs to Cardiovascular.
Por que acontece
Additive myotoxicity with possible OATP1B1 inhibition
O que fazer
Avoid where possible; if both are needed use the lowest fluvastatin dose, and advise patients to report muscle pain or dark urine; check CK if symptomatic.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Fluvastatin
- Cyclosporine + Fluvastatin Grave
- Cyclosporin + Fluvastatin Grave
- Fluvastatin + Letermovir Grave
- Fluvastatin + Red yeast rice Grave
- Apalutamide + Fluvastatin Moderada
- Cholestyramine + Fluvastatin Moderada
Outras interações de Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicada
- Elagolix + Gemfibrozil Contraindicada
- Gemfibrozil + Mavacamten Contraindicada
- Gemfibrozil + Metformin-repaglinide Contraindicada
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicada
- Gemfibrozil + Repaglinide Contraindicada
Perguntas frequentes
Can I take Fluvastatin with Gemfibrozil?
MediHelp rates the interaction as major. Fluvastatin and Gemfibrozil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gemfibrozil inhibits OATP1B1 and glucuronidation and fibrates also have intrinsic myotoxicity, which can raise statin exposure. Fluvastatin is mainly cleared by CYP2C9, so the pharmacokinetic rise is smaller than for other statins, but myopathy and rhabdomyolysis remain possible.
How serious is the interaction between Fluvastatin and Gemfibrozil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid where possible; if both are needed use the lowest fluvastatin dose, and advise patients to report muscle pain or dark urine; check CK if symptomatic.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporine, Cyclosporin, Letermovir. The full list is on the Fluvastatin page.
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