Interações medicamentosas
Cyclosporin + Ixekizumab
Gravidade: Leve
Cyclosporin and Ixekizumab: minor interaction.
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Resumo
Reduced inflammation during IL-17A blockade may restore CYP450 activity that was suppressed by cytokines, theoretically lowering cyclosporine concentrations. A clinically important effect has not been established. Combined immunosuppression also raises infection concerns.
O que esta interação significa em palavras simples
Cyclosporin and Ixekizumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclosporin belongs to Miscellaneous; Ixekizumab belongs to Miscellaneous.
Por que acontece
Cytokine normalization may modestly increase CYP-mediated cyclosporine metabolism; this is theoretical.
O que fazer
Check cyclosporine trough levels and clinical response when ixekizumab is started or stopped. Monitor for infection.
O que perguntar ao farmacêutico
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Outras interações de Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicada
- Aliskiren + Cyclosporin Contraindicada
- Bcg vaccine live + Cyclosporin Contraindicada
- Bosentan + Cyclosporin Contraindicada
- Cidofovir + Cyclosporin Contraindicada
- Cyclosporin + Dengue vaccine Contraindicada
Outras interações de Ixekizumab
Perguntas frequentes
Can I take Cyclosporin with Ixekizumab?
MediHelp rates the interaction as minor. Cyclosporin and Ixekizumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Reduced inflammation during IL-17A blockade may restore CYP450 activity that was suppressed by cytokines, theoretically lowering cyclosporine concentrations. A clinically important effect has not been established. Combined immunosuppression also raises infection concerns.
How serious is the interaction between Cyclosporin and Ixekizumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check cyclosporine trough levels and clinical response when ixekizumab is started or stopped. Monitor for infection.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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