Interações medicamentosas
Ixekizumab + Lomustine
Gravidade: Moderada
Ixekizumab and Lomustine: moderate interaction.
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Resumo
Lomustine causes myelosuppression and immune suppression, while ixekizumab blocks IL-17A signaling and impairs host defense. Together they may raise the risk of serious bacterial, fungal or opportunistic infections.
O que esta interação significa em palavras simples
Ixekizumab and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ixekizumab belongs to Miscellaneous; Lomustine belongs to Oncology.
Por que acontece
Additive immunosuppression: cytotoxic marrow suppression plus IL-17A antagonism.
O que fazer
Screen for active infection before and during therapy and monitor neutrophil counts. Hold ixekizumab if a serious infection develops.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicada
- Bcg vaccine live + Lomustine Contraindicada
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicada
- Lomustine + Measles mumps and rubella vaccine Contraindicada
- Lomustine + Measles mumps and rubella vaccine live Contraindicada
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicada
Outras interações de Ixekizumab
Perguntas frequentes
Can I take Ixekizumab with Lomustine?
MediHelp rates the interaction as moderate. Ixekizumab and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomustine causes myelosuppression and immune suppression, while ixekizumab blocks IL-17A signaling and impairs host defense. Together they may raise the risk of serious bacterial, fungal or opportunistic infections.
How serious is the interaction between Ixekizumab and Lomustine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Screen for active infection before and during therapy and monitor neutrophil counts. Hold ixekizumab if a serious infection develops.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.
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